Shape Discrimination by Total Curvature with a view to Cancer Diagnostics
by R. J. Gardner, A. Hobolth, E. B. V. Jensen and F. B. Sørensen
Research Reports
Number 440 (January 2004)
This paper studies the use of total curvature for shape discrimination of objects via profiles of their planar sections (not assumed star shaped). Methods of estimating total curvature from observation of a finite number of points on the boundary of the object are investigated, including a simple discrete approximation method and various interpolation methods. Total curvature is capable of revealing shape differences on a local scale, as demonstrated by the analysis of two data sets of malignant and normal or benign tumor cell nuclear profiles.
Published in J. Microsc. 217, 49-59 (2005)
This primarily serves as Thiele Research Reports number 2-2004, but was also published in Research Reports